People are vaccinated at the Palais de Congress COVID-19 vaccination clinic, Thursday, May 13, 2021 in Montreal.THE CANADIAN PRESS/Ryan Remiorz

People are vaccinated at the Palais de Congress COVID-19 vaccination clinic, Thursday, May 13, 2021 in Montreal.THE CANADIAN PRESS/Ryan Remiorz

Canadian maker of promising mRNA vaccine looks to test it against Pfizer in new trial

Calgary-based Providence Therapeutics says its vaccine produced no serious adverse events and developed good antibodies against COVID-19

A homegrown mRNA vaccine for COVID-19 shows promising results in its first small trial and its maker is hoping to test it directly against the vaccine from Pfizer-BioNTech.

Calgary-based Providence Therapeutics says its vaccine produced no serious adverse events and developed good antibodies against COVID-19 that “compare favourably” with the two mRNA vaccines already on the market from Pfizer and Moderna.

“We’re extremely pleased,” said Providence CEO Brad Sorenson.

The Phase 1 trial included 60 healthy adults between 18 and 64, with more than half of them receiving two doses of the vaccine, four weeks apart. The results have not yet been peer-reviewed.

Sorenson said the next step is supposed to be a Phase 2 head-to-head trial that would test the effectiveness of Providence against Pfizer. Most vaccines in Phase 2 have been tested only against a placebo, but Sorenson said in a pandemic he feels it is unethical to give someone a placebo when they could otherwise be vaccinated.

But to do the trial, Providence needs 500 doses of Pfizer, which he said neither the company nor the National Research Council has been willing to provide.

A spokeswoman for Pfizer said Thursday the company’s focus is only on getting the vaccine to meet an “urgent public health need” and will only sell its vaccine to the federal government.

“As such, we are not providing supply of our vaccine to third-parties to study the vaccine in comparative trials,” said Christina Antoniou.

Pfizer is the main component of Canada’s vaccination campaign to date, accounting for two-thirds of the deliveries as of this week.

A spokesman for Innovation Minister François-Philippe Champagne said the government has informed Providence Ottawa is willing to help fund its Phase 2 trial, and continue to work with the company.

“Minister Champagne has spoken directly with Providence Therapeutics’ CEO and the chair of their board of directors to discuss our continued support for their work as they bring their vaccine candidate through the early stages of development,” said John Power.

A spokesman for the National Research Council said it doesn’t have access to doses of Pfizer or Moderna to help Providence, but is discussing the request with other departments that might be able to help, including Health Canada and the Public Health Agency of Canada.

Sorenson said Providence is also discussing with the World Health Organization the possibility of doing a Phase 3 trial in a developing country.

Sorenson said if Health Canada supports both trials, they could be wrapped up by the end of the year. But Sorenson said he doesn’t feel supported by Ottawa and has threatened to take the business outside the country.

The company has production agreements in place that should be able to produce 200 million doses a year, he said.

Providence is one of six Canadian companies that received funding from the National Research Council for COVID-19 vaccines that were in early stages of development.

The company received $4.9 million last October to help fund its Phase 1 trial. It also received $5 million in January from the next-generation manufacturing supercluster to help scale up its manufacturing of mRNA.

Canada currently doesn’t make any of the vaccines it is using — Pfizer is being made in Europe and the United States, Canada’s doses of Moderna are all coming from Europe, and Oxford-AstraZeneca is coming from the United States, India and South Korea.

The only Canadian-made vaccine among the seven procured by Canada for COVID-19 to date is Medicago’s plant-based protein vaccine, which is now in a Phase 3 trial and could be ready for mass production before the end of the year.

Medicago received $173 million in October to push its vaccine forward as well as an undisclosed sum for a contract to provide Canada at least 20 million doses if it is approved. Some of it will be made in Canada, but production will also take place in the U.S.

A lack of domestic drug manufacturing hurt Canada’s vaccination program, particularly early on, and Prime Minister Justin Trudeau said the government is intent on fixing that ahead of the next global health crisis.

Like us on Facebook and follow us on Twitter.

Want to support local journalism? Make a donation here.

Coronavirus

Just Posted

Alberta is now below 3,000 active cases of COVID-19, as the province reported 2,639 Wednesday. (NIAID-RML via AP)
Red Deer below 100 active COVID-19 cases for first time since March

69.7 per cent of Albertans 12 and over have at least one dose of the COVID-19 vaccine

Premier Jason Kenney says the provincial government is doing everything it can to encourage Albertans to get vaccinated. (Photo by Chris Schwarz/Government of Alberta)
Travel prizes added to Alberta’s vaccine lottery

More than 40 travel rewards available for those who are fully vaccinated

Town of Castor
Town of Castor meeting highlights for June 14th

The Town has appointed a returning officer for this fall’s municipal elections

(Advocate file photo)
Red Deer down to 102 active COVID-19 cases

Central zone has 332 cases with 26 in hospital and five in ICU

Members of Castor Volunteer Fire Rescue were out about the town on June 8th doing Self Contained Breathing Apparatus training and contributing to the month-long ParticipACTION fitness challenge for the Paintearth Choosewell team, which currently sits in third place in the province. 
photo submitted
Members of Castor Volunteer Fire Rescue were out June 8th doing Self Contained Breathing Apparatus training

They were also contributing to the month-long ParticipACTION fitness challenge for the Paintearth Choosewell team

People watch a car burn during a riot following game 7 of the NHL Stanley Cup final in downtown Vancouver, B.C., in this June 15, 2011 photo. THE CANADIAN PRESS/Geoff Howe
10 years ago: Where were you during the 2011 Vancouver Stanley Cup Riots?

Smashed-in storefronts, looting, garbage can fires and overturned cars some of the damage remembered today

A screenshot of the First Peoples Cultural Councils First Peoples’ Map. (First Peoples Cultural Council)
Online resource blends B.C.’s Indigenous language, art and culture

Advisor says initiative supports the urgent need to preserve Indigenous languages

A plane is silhouetted as it takes off from Vancouver International Airport in Richmond, B.C., May 13, 2019. THE CANADIAN PRESS/Jonathan Hayward
Report calls for airlines to refund passengers for flights halted due to COVID-19

Conclusion: federal help should be on the condition airlines immediately refund Canadian travellers

Green party Leader Annamie Paul speaks during a news conference on Parliament Hill in Ottawa on Tuesday, June 15, 2021. Paul has survived another day of party strife after a planned ouster shifted course, leaving her with a tenuous grip on power ahead of a likely federal election this year. THE CANADIAN PRESS/Justin Tang
Green Leader Annamie Paul blasts ‘racist,’ ‘sexist’ party execs who sought ouster

Fallout has continued, with two of the federal council’s members resigning

Russian President Vladimir Putin, left, and U.S President Joe Biden shake hands during their meeting at the ‘Villa la Grange’ in Geneva, Switzerland in Geneva, Switzerland, Wednesday, June 16, 2021. (AP Photo/Alexander Zemlianichenko, Pool)
Biden says meeting with Putin not a ‘kumbaya moment’

But U.S. president asserted Russian leader is interested in improved relations, averting a Cold War

A nurse prepares a shot of the COVID-19 vaccine at the Yukon Convention Centre in Whitehorse on Wednesday, March 3, 2021. THE CANADIAN PRESS/Mike Thomas
Vancouver couple pleads guilty to breaking Yukon COVID rules, travelling for vaccine

Chief Judge Michael Cozens agreed with a joint sentencing submission,

People line up to get their COVID-19 vaccine at a vaccination centre, Thursday, June 10, 2021 in Montreal. THE CANADIAN PRESS/Ryan Remiorz
Vaccines, low COVID case counts increase Father’s Day hope, but risk is still there

Expert says people will have to do their own risk calculus before popping in on Papa

COVID-related trash is washing up on shorelines across the world, including Coldstream’s Kal Beach, as pictured in this May 2021 photograph. (Jennifer Smith - Black Press)
Shoreline cleanup finds COVID-related trash increased during height of the pandemic

Great Canadian Shoreline Cleanup reports litter from single-use food packaging nearly doubled

Doctor David Vallejo and his fiancee Doctor Mavelin Bonilla hold photos of themselves working, as they kiss at their home in Quito, Ecuador, Wednesday, June 9, 2021. Doctor Vallejo and Doctor Bonilla suspended their wedding in order to tend to COVID-19 patients and in the process Vallejo got sick himself with the disease, ending up in an ICU for several days. (AP Photo/Dolores Ochoa)
Love, sacrifice and surviving COVID-19: one couple’s story

COVID hits Ecuadorian doctors who delayed wedding to treat sick

Most Read